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Brain functional connectivity network breakdown and restoration in blindness
| Type of publication: | Article |
| Citation: | |
| Journal: | Neurology |
| Volume: | 83 |
| Number: | 6 |
| Year: | 2014 |
| Month: | August |
| Pages: | 542---441 |
| URL: | http://www.neurology.org/conte... |
| DOI: | 10.1212/WNL.0000000000000672 |
| Abstract: | Objective: To characterize brain functional connectivity in subjects with prechiasmatic visual system damage and relate functional connectivity features to extent of vision loss. Methods: In this case-control study, resting-state, eyes-closed EEG activity was recorded in patients with partial optic nerve damage (n = 15) and uninjured controls (n = 13). We analyzed power density and functional connectivity (coherence, Granger causality), the latter as (1) between-areal coupling strength and (2) individually thresholded binary graphs. Functional connectivity was then modulated by noninvasive repetitive transorbital alternating current stimulation (rtACS; 10 days, 40 minutes daily; n = 7; sham, n = 8) to study how this would affect connectivity networks and perception. Results: Patients exhibited lower spectral power (p = 0.005), decreased short- (p = 0.015) and long-range (p = 0.033) coherence, and less densely clustered coherence networks (p = 0.025) in the high-alpha frequency band (11–13 Hz). rtACS strengthened short- (p = 0.003) and long-range (p = 0.032) alpha coherence and this was correlated with improved detection abilities (r = 0.57, p = 0.035) and processing speed (r = 0.56, p = 0.049), respectively. Conclusion: Vision loss in the blind is caused not only by primary tissue damage but also by a breakdown of synchronization in brain networks. Because visual field improvements are associated with resynchronization of alpha band coherence, brain connectivity is a key component in partial blindness and in restoration of vision. |
| Keywords: | blindness, functional connectivity |
| Authors | |
| Added by: | [CM] |
| Total mark: | 0 |
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